Hydroxyarylarsenoxid.



PAUL seamen AND ALFRED BERTHEIM, OF FRAINKFORT-ONLTTHE-MAIN, GERMANY,- assrenons TO FARBWERKE VORM. MEISIER LUCIUS & BRUNING, or HOCHST-ON;

THE-MAIN, GERMANY, A conPenATIoN or GERMANY.

HYDRQXYARYLARSENOXID No. comma.

Specification of Letters Patent. I

i Patented Dec. 29, 1908.

To all whom it may concern:

Be it known that we, PAUL EHRLICH, M. 1)., professor of medicine, and AL ,RED BERTHEIM, Ph. D., both citizens of the mpire of Germany, and residing at Frankforton-thaMain, Germany, have invented certain new and useful improvements in Hyis a specification We have found that the hydroxyarylarsenoxids oirtainabie by'reducing'liydroxy arylarsinic'acids possess valuable properties for pharmaceutical use; they are used for therapeutical disinfecting purposes and as parent material in making the arsenophenols.

The hitherto unknown hydroxyarylarsenoxids are white crystallized compounds, the constitution of which corresponds, to the formula HO;Aryl-As=0 They are readily soluble in water, alcohol,

acetone and glacial acetic acid, diflicultly soluble in benzene, chloroform and carbonbisulfid. Their aqueous solution shows with ferric chlorid a dirty violet color. With alkalies they form salts which are soluble in water.

The hydroxyarylarsenoxids are obtained by the action of weak reducing agents on oxyarylarsinic acids: as for instance parahydroxyphenylarsimc acid; hydroxytolylarsimc acid or hyd roxyxylylarsinic acid ounncnogoir-A oannoiraonmosnw114:2:5

The formation of the hydroxyarylarsenoxids from the hydroxyarylarsinic acids corresponds to the equation:

l-I0'Aryl ---AsO H2+H2=HOAryl--AsO+EH20.

By the action of hydrosulfite or sodium amalgam the hydroxyarylarsenoxids turn into yellow-brown arsenophenols which form yellow colored alkali salts. For instance,

the preparation of the para-h -droxyphenylarsenoxid is carried out as follows: 114 parts of parahydroxyphenylarsinic acid, which can vin 14 times their quantity of Water.

be produced by decomposing the diazotizedpara-amidophenylarsinic acids, are dissolved To this solution 20 parts by weight of iodid of potassium and 600 parts by weight of 20% sulfuric acid are added,vand then it is saturated at ordinary temperature with sulfurous acid. After having allowed the solution to stand for a little while, it is saturated with sodium chlorid, and extracted b means gig-tiger. The ethereal extract is sha en with saturated solution of soda and after separating the solution the ether is distilled off. Thereupon the phenolarsenoxid remains in the form'of a white-crystalline substance the properties of which are those given'in the above general description of hydroxyarylarsenoxids; it can, without becoming decomposed, be heated up to 240 C. If neutral sodiumhydrosulfite be added to the aqueous solution of hydroxyphenylarsenoxid and gently heated on the water-bath, arsenophenol separates in the form of yellow-brown flakes.

Having now described'our invention, what we claim 1s:

1. As new products, the hydroxyaiylan senoxids, the constitution of which corrc sponds to the formula:

OHAry 1-As=Q being white crystalline bodies, which are readily soluble in water, alcohol, ether and glacial acetic acid, and difiicultly soluble in benzene, chloroform and carbon bisulfid,

their aqueous solution when treated with being a white'crystalli-ne compound which is readily soluble in water, alcohol, ether and glacial acetic acid, and difiicultly solublein benzene, chloroform and carbon bisulfid, the

as our inven tiou,"have' signed our flames in presence of two subscribing witnesses.

PAUL EHRLIOH, ALFRED BERTHEIM.

a) ueous solution of which with ferric chlorl assumes a dirty violet color, and which with alkalies form salts which are soluble in Water and said compound in neutral solution swing-transformed by hydrosulfite into arsenophenol of a yellow-brown color.

In testimony, that We claim the foregoing Witnessesz JEAN GRUND, CARL GRUND. 

